Skip Navigation

European Heart Journal 1983 4(2):110-116;
Copyright © 1983 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by FIORETTI, P.
Right arrow Articles by CAMERINI, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FIORETTI, P.
Right arrow Articles by CAMERINI, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983 The European Society of Cardiology

Acute hemodynamic effects of nifedipine at rest and during stress in severe aortic incompetence

P. FIORETTI, B. BENUSSI, S. KLUGMANN and F. CAMERINI

Divisione di Cardiologia, Ospedale Maggiore e Cattedra di Fisiopatologia Cardiocircolatoria, Universita di Trieste Italy

Received 15 September 1981; revised 16 March 1982; .

Requests for reprints to: Dr Paolo Fioretti, Thoraxcentrum, KW 1200. Academisch Ziekenhuis Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Abstract

To determine whether afterload reduction with nifedipine is effective both at rest and during stress tests (rapid atrial pacing and contrast material overload), 14 patients with chronic severe isolated aortic insufficiency (10 asymptomatic) underwent right and left cardiac catheterization.

Forty-five minutes after 20 mg of nifedipine (sublingually), left ventricular end-diastolic pressure, peak aortic pressure, systemic vascular resistance and double product decreased significantly at rest, at peak paced rate, and after angiography (P values from <0.05 to <0.001). Cardiac index increased at resting heart rate (P<0.01) but was unchanged during pacing. The reduction of systemic vascular resistances was inversely correlated with its initial value (r = –0.69).

After nifedipine, average regurgitant fraction did not change; however its variations were significantly correlated with those of systemic vascular resistance (r = 0.69).

It is concluded that in severe aortic insufficiency, nifedipine induces an effective reduction of left ventricular pre- and afterload, accompanied by an enhanced mechanical efficiency (unchanged or increased cardiac index with lower double product), both at rest and during stress tests.

Key Words: Afterload reducing agents • calcium antagonist drugs • left ventricular function • stress tests


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
G. Kouvaras, G. Chronopoulos, P. Nikolaou, G. Sofronas, and D. Cokkinos
Effect of Nifedipine on the Sick Sinus Syndrome
Angiology, May 1, 1989; 40(5): 450 - 457.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.