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European Heart Journal 1983 4(4):272-279;
Copyright © 1983 by the European Society of Cardiology.
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© 1983 The European Society of Cardiology

Quantification of infarct size in the dog by Thallium-201 single photon emission transaxial tomography (SPETT)

J. MAUBLANT*, P. GACHON, N. MOINS and P. DUCHENE-MARULLAZ

Department of Nuclear Medicine, Centre Jean Perrin, and the Department of Pharmacology, U.195 INSERM, Faculty of Medicine, University of Clermont-Ferrand France

Received 8 January 1982; revised 14 July 1982; .

Reprint requests to: Jean Maublant, MD, Centre Jean Penin, F-63011 Clermont-Ferrand, France.

Abstract

In a series of 12 dogs having an acute experimental anterior myocardial infarct, the size of the infarct was measured using, successively, single photon emission transaxial tomography (SPETT) with thallium-201, conventional planar scintigraphy of the anatomic slices, and planimetry of these slices after nitroblue-tetrazolium (NBT) staining. The tomographic views were obtained after processing of projection images collected during the rotation of a scintillation camera around the animals. A correlation of 0.86 was obtained between SPETT and NBT staining for the whole series, and a value of 0.94 was observed when only the transmural infarcts were considered. These results suggest that SPETT of the myocardium labelled with thallium-201 should allow a reliable, rapid and atraumatic estimation of the infarct size.

Key Words: Thallium-201 • emission tomography • infarct size


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