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European Heart Journal 1983 4(4):280-285;
Copyright © 1983 by the European Society of Cardiology.
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© 1983 The European Society of Cardiology

Iopamidol: a new contrast medium in coronary angiography

Comparison, on electrophysiological changes in man, with a commonly used contrast medium

L. NICCOLI, M. BELLANDI, C. CUCCIA, V. PETROBONI and O. VISIOLI

Cattedra di Cardiologia, Universit{acute}degli Studi di Brescia and Divisione di Cardiologia, Spedalt Civili di Brescia P. le Spedale Civili 1-25100 Brescia, Italy

Received 28 April 1982; revised 16 July 1982; .

Abstract

In 30 patients undergoing coronary angiography the effects of lopamidol on sinus node activity, atrioventricular and intraventricular conduction were evaluated using His Bundle recordings, and compared to the effects produced by Diathzoate.

Diatrizoate resulted in an increase in sinus cycle length and prolonged AV nodal conduction, resulting in second degree A V block in two patients, lopamidol had significantly less effect on sinus cycle (P<0.01) and AV nodal conduction (P<0.01). Neither contrast media affected intraventricular conduction. No difference was noted in the imaging power of the two contrast media.

It is suggested that non-ionic, low osmotic contrast media such as lopamidol will result in increased patient safety during coronary angiography without loss of imaging power.

Key Words: Contrast media • coronary angiography complications • His Bundle recording


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