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European Heart Journal 1983 4(6):383-390;
Copyright © 1983 by the European Society of Cardiology.
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© 1983, by the European Society of Cardiology

Familial inducible torsade de pointes with normal QT interval*

B. STRASBERG, W. WELCH, E. PALILEO, S. SWIRYN, R. BAUERNFEIND and K. M. ROSEN*

Section of Cardiology, Department of Medicine, Abraham Lincoln School of Medicine, University of Illinois College of Medicine Chicago, Illinois, USA

Received 23 March 1982; revised 16 September 1982; .

Reprint requests to: Dr Strasberg at his present address: Coronary Care Unit, Beilinson Medical Center, Petah Tiqva 49 100, Israel.

Abstract

A familial presentation of torsade de pointes is described. The propositus had recurrent syncope, documented torsade de pointes, a normal Q-T, and close coupled premature ventricular beats initiating the paroxysmal arrhythmia. The mother had sporadic syncope without documented torsade de pointes, a normal Q-T, and closely coupled premature ventricular beats. Electrophysiological studies demonstrated reproducible inducible torsade de pointes tachycardia in both patients. Serial drug testing in both revealed suppression of induced torsade de pointes with oral propranolol. Chronic oral propranolol resulted in clinical cure in both patients.

Key Words: Torsade de pointes • Q-T interval • syncope • electrophysiological studies • Propranolol


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