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European Heart Journal 1983 4(7):496-501;
Copyright © 1983 by the European Society of Cardiology.
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© 1983, by the European Society of Cardiology

Haemodynamic and clinical effects of long-term treatment of essential hypertension with captopril

B. RICCIARDELLI, M. VOLPE, B. TRIMARCO, N. DE LUCA, A. CUOCOLO, L. SACCA’ and M. CONDORELLI

Istituto di Patologia Speciale Medica e Metodologia Clinica, II Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Via S. Pansini 5, 80131 Napoli, Italy

Received 20 May 1982; revised 13 September 1982; .

Abstract

Captopril, an orally active inhibitor of angiotensin converting enzyme, was administered for 12 months to 20 patients with mild or moderate essential hypertension who initially responded favourably to this pharmacological treatment. Captopril induced a significant reduction in blood pressure which remained unmodified throughout the study. This fall in blood pressure was mainly due to a significant decrease in total peripheral vascular resistance, since no change in cardiac output was observed. Simultaneously, there was no significant change in left ventricular anatomy and performance evaluated by echocardiographic technique.

Key Words: Echocardiography • cardiac hypertrophy • plasma renin activity


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