Skip Navigation

European Heart Journal 1983 4(8):566-572;
Copyright © 1983 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by COMA-CANELLA, I.
Right arrow Articles by LOPEZ-SENDON, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by COMA-CANELLA, I.
Right arrow Articles by LOPEZ-SENDON, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983, by the European Society of Cardiology

Haemodynamic effects of nifedipine, nitroglycerine and prazosin in pulmonary hypertension following ingestion of toxic oil

I. COMA-CANELLA and J. LOPEZ-SENDON

Coronary Care Unit, Servicio de Coronariopatias, Departamento de Medicina Interna Ciudad Sanitaria La Paz, Madrid, Spain

Received 14 September 1982; revised 24 November 1982; .

Address for reprints. I. Coma-Canella, Unidad Coronaria, Ciudad Sanitaria La Paz, Madrid-34, Spain.

Abstract

The haemodynamic effect of several vasodilators was studied in 15 patients with pulmonary hypertension of recent onset secondary to ingestion of toxic oil. Right heart catheterization was performed by means of a Swan-Ganz thermodilution catheter. Mean pulmonary artery pressure (xAx) was higher than 25 mmHg in every patient. Haemodynamic monitoring was maintained for 2–3 days and three drugs were administered.

Nifedipine (10 mg sut lingual plus 20 mg p.o.) produced slight reductions in xAx and pulmonary artery resistance (PAR) at some time after drug administration. These changes were minimal and the drug was not considered useful. Nitroglycerine ointment (20–25 mg) produced a significant decline in xAx and PAR throughout six hours although prominent changes occurred only at the first hour. Prazosin (5–10 mgp.o.) induced a significant decline in PAR and xAx throughout 6 hours. The effect of this drug was more prominent than that of nitroglycerine.

Key Words: Pulmonary hypertension • vasodilators • nifedipine • nitroglycerine • prazosin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.