Skip Navigation

European Heart Journal 1983 4(9):647-654;
Copyright © 1983 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by FLAMMANG, D.
Right arrow Articles by COUMEL, Ph.
Right arrow Search for Related Content
PubMed
Right arrow Articles by FLAMMANG, D.
Right arrow Articles by COUMEL, Ph.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983, by the European Society of Cardiology

Electrophysiological profile of bepridil, a new anti-anginal drug with calcium blocking properties

D. FLAMMANG*,, M. WAYNBERGER*, F. H. JANSEN{dagger}, R. PAILLET{dagger} and Ph. COUMEL{ddagger}

*Department of Cardiology, Angoul{circumflex}me General Hospital 16470 Saint Michel, France
{dagger}Department of Clinical Research of CERM 63201 Riom, France
{ddagger}Department of Cardiology, Lariboisiere Hospital 2, rue Ambroise Paré 75010 Paris, France

Received 17 March 1981; revised 31 July 1982; .

Requests for reprints to: D. Flammang M.D., Department of Cardiology, Centre Hospitalier d' Angoulême, 16470 Saint Michel, France.

Abstract

The electrophysiological effects of intravenously administered bepridil, a new anti-anginal drug with slow calcium current blocking properties, were studied in 20 patients undergoing an endocavitary cardiac exploration for various reasons. Classical techniques of programmed electrical stimulation were used. Bepridil markedly increased the refractory period of the atrium, atrioventricular node and the AH- interval. The effects on HR and ventricular refractory period were minimal, and sinus rate decreased slightly. A pronounced reduction in the heart rate at which the Wenckebach phenomenon was obtained in the anterograde direction (16%) and particularly in the retrograde direction (26%) was observed.

During this study the drug appeared beneficial in suppressing atrial flutter, atrial extrasystoles, and ventricular extrasystoles. In two patients with intranodal reciprocal rhythm, the injection of bepridil terminated the tachycardia which could not be reinitiated later. No side-effects occurred and it appears that bundle branch block and prolonged HV interval are not contraindications to the use of bepridil.

Key Words: Calcium antagonist • anti-arrhythmic drug • clinical electrophysiology


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.