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European Heart Journal 1984 5(1):27-34;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

The effects of atropine on sinoatrial conduction time directly measured from sinus node electrogram. A comparison with results furnished by indirect methods

L. PADELETTI, A. MICHELUCCI, G.A. FRADELLA, D. MONIZZI and F. FANTINI

Cattedra di Malatlie Cardiovascolari Universita di Firenze Italy

Received 18 February 1983; revised 5 June 1983; .

Requests for Reprints Dr Luigi Padeletti, Via G. Modena, 19, 50121 Firenze, Italy.

Abstract

The effects of atropine on sinoatrial conduction time (SACT) measured directly (SACTD)from the sinus node electrogram (SNE) were investigated in 15 patients with normal sinus node function. A comparison was undertaken with the results furnished by indirect methods which employ premature (SACTS) and asynchronous atrial stimulation (SACTN) to calculate SACT. In the control stale SACTD was 92-5±16-4ms. SACTS 78-2±22 ms, and SACTN 97-9±32-2 ms. After atropine SACTD was 70-6±15-6ms (P<0-0O05), SACTS 46-7±14-3ms (P<0-0005) and SACTN 43-1 ±12-7 ms (P<00005). Mean percent decreases of SACTN (51-6 ± 21) and SACTS (37-4±18) were statistically greater than that of SACTD (23-5±13-3) (P<0-0005 and P<001 respectively). While the reduction of SACTS and SACTN was greater than that of sinus cycle length (SCL) (29-2%), SACTD showed a reduction significantly less than that of SCL (P<0-005). Thus, SNE recording confirms that atropine induces a shortening of SACT in normal patients, but significantly less than that indicated by indirect methods.

Key Words: Atropine • Sinus node • Sinoatrial conduction


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