Copyright © 1984 by the European Society of Cardiology.
© 1984 The European Society of Cardiology
Provocation of variant angina by alcohol ingestion*
Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan
Received 29 November 1983; revised 3 August 1984; .
Address for Correspondence: Motoomi Nakamura. MD. Research Institute of Angiocardiology and Cardiovascular Clinic. Faculty of Medicine, Kyushu University, 3-1-1 Maidashi. Higashi-ku. Fukuoka 812, Japan.
Abstract
The effect of alcohol on variant angina was studied in six patients who had a history of chest pain occurring with alcohol ingestion. On alcohol testing, Holter ECG monitoring was performed and a 12-lead ECG was recorded at the time of chest pain. In five, chest pain with ST elevation occurred 5.5 to 17.5 h after the ingestion of alcohol (100 to 150 ml as ethanol). These showed recurrent ST elevation on Holter ECG, most episodes being asymptomatic. Results of provocation testing were reproducible in all four patients in whom tests were repeated and ST elevation occurred in the same leads. No complications were observed. The Holter ECG revealed a higher heart rate after alcohol ingestion. The plasma level of alcohol was zero when angina occurred and plasma epinephrine, norepinephrine and serotonin were unchanged following alcohol ingestion. Alcohol ingestion may be a useful method of provoking variant angina, particularly in those who have a history of angina related to alcohol ingestion.
Key Words: Coronary vasospasm • alcohol induced variant angina • Holter ECG • serotonin • catecholamines
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