Copyright © 1984 by the European Society of Cardiology.
© 1984 The European Society of Cardiology
The deleterious effects of myocardial catecholamines on cellular electrophsiology and arrhythmias during ischaemia and reperfusion
Department of Cardiology, Welsh National School of Medicine Health Park, Cardiff CF4 4XY, U.K.
Abstract
Action potentials and ECGs were recorded from Langendorff perfused guinea pig hearts during ischaemia and reperfusion. Arrhythmias were significantly more frequent during low flow (10% of control) than zero flow ischaemia and were most frequent during reperfusion following 30 minute ischaemia. Arrhythmias during low flow ischaemia were preceded by spontaneous recovery in action potential amplitude and 
max and marked shortening of refractory period which did not occur during zero flow ischaemia. Reperfusion VF was always preceded by further shortening of the action potential.
Myocardial catecholamine deplection, by pre-treatment with 6-hydroxydopamine significantly reduced the incidence of arrhythmias during ischaemia and reperfusion. Catecholamine depletion blunted the ischaemia induced reduction in action potential amplitude and max, prevented any spontaneous recovery and abolished reperfusion induced shortening of action potential duration. Methoxamine given to catecholamine depleted hearts, having only minor effects during normal perfusion, significantly reverfusion. Phentolamine and proproanolol in anti-arrhythmic concentrations, profoundly modified the electrophysiological effects of ischaemia and reperfusion.
These results suggest that release of endogenous myocardial catecholamines contributes through 
and ß-adrenoceptor stimulation to the electrophysiological changes and arrhythmias during myocardial ischaemia and reperfusion.
Key Words: Cellular-electrophysiology • arrhythmias • catecholamines • ishaemia • reperfusion
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