Copyright © 1984 by the European Society of Cardiology.
© 1984 The European Society of Cardiology
The multiple modes of action of propafenone
Department of Pharmacology, Oxford University Oxford OX 1 3QT, U.K.
Received 8 September 1983; revised 7 November 1983; .
Address for reprints: Department of Pharmacology, South Parks Road, Oxford 0X1 3QT.
Abstract
Previous studies of widely different concentrations of propafenone in various species have reported that in addition to having class 1 antiarrhythmic action, the drug was a beta adrenoceplor blocker and a calcium antagonist. High concentration shortened action potential duration in animal experiments, but Q-T interval was reported as being lengthened in man. It was thought desirable to study the effects of propafenone over a range of concentrations equivalent to those used clinically in various cardiac tissues of a single species, the rabbit. It was concluded that although the primary action of propafenone was on fast inward current, the drug being categorised as of group Ic, its potency as a beta blocker was sufficient for the effect to be of clinical significance. Its potency as a calcium antagonist was relatively weak. Action potential duration and effective refractory period were lengthened in both atrium and ventricle, the effects being long-lasting and persisting on wash-out of the drug when other measurements had returned to control values.
Key Words: Beta blockade • calcium antagonism • antiarrhythmic drugs • microelectrode • action potential-duration • fast inward current
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