Skip Navigation

European Heart Journal 1984 5(2):99-107;
Copyright © 1984 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by MILNE, J. R.
Right arrow Articles by JOHN CAMM, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MILNE, J. R.
Right arrow Articles by JOHN CAMM, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1984 The European Society of Cardiology

Class 1 antiarrhythmic drugs-Characteristic electrocardiographs differences when assessed by atrial and ventricular pacing

J. R. MILNE1, K.J. HELLESTRAND, R.S. BEXTON, P.J. BURNETT*, N.M.G. DEBBAS and A. JOHN CAMM{dagger}

Department of Cardiology, St Bartholomew's Hospital West Smithfield, London EC1 A 7BE, U.K.

Received 7 February 1983; revised 27 October 1983; .

Address for reprints:Dr.J.R.Milne,Department of Cardiology,St Batholomew's Hospital,West Smithfield,London ECIA 7BE

Abstract

Class 1 antiarrhythmic drugs have been subdivided into la, lb and lc according to their effect on the action potential duration. The effects on the surface electrocardiogram of one drug from each subgroup were investigated in nine patients. Electrocardiographs recordings were taken during sinus rhythm and at identical atrial and ventricular paced rates. Disopyramide (la) significantly prolonged the QT interval during sinus rhythm and at the identical paced rates, by increasing both the QRS duration and JT interval. Lignocaine (lb) significantly reduced the Q T interval during sinus rhythm and at the identical paced rates, by reducing the JT interval. Lignocaine had no effect on the QRS duration. Flecainide (lc) significantly prolonged the QRS duration during sinus rhythm, but not the Q Tc. However the Q T interval at the paced rates prolonged significantly, due entirely to an increase of the QRS duration. Flecainide had no effect on the JT interval. These characteristic electrocardiographic differences support the differentiation of class 1 drugs into three separate subgroups.

Key Words: Class 1 antiarrhythmic drugs • QT interval • JT interval • repolarization


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
M. V. Pitzalis, M. Anaclerio, M. Iacoviello, C. Forleo, P. Guida, R. Troccoli, F. Massari, F. Mastropasqua, S. Sorrentino, A. Manghisi, et al.
QT-interval prolongation inright precordial leads: an additional electrocardiographic hallmark of Brugada syndrome
J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1632 - 1637.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
N. M. G. Debbas, S. H. D. Jackson, D. de Jonghe, A. Robert, and A. J. Camm
Human atrial repolarization: effects of sinus rate, pacing and drugs on the surface electrocardiogram
J. Am. Coll. Cardiol., February 1, 1999; 33(2): 358 - 365.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
R. Leor, B. Rabinowitz, H. Hod, and E. Kaplinsky
An Undocumented Effect of Lidocaine Revealed by Computerized Electrocardiography
Angiology, July 1, 1993; 44(7): 517 - 522.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.