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European Heart Journal 1984 5(3):243-246;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

Electrophysiological effects of ethmozin on sinus nodal function in patients with and without sinus node dysfunction

P. RAKOVEC1, J. JAKOPIN, P. RODE, M.F. KENDA and M. HORVAT

Centre of Cardiovascular Diseases and Centre of Intensive Internal Medicine, University Clinical Centre Ljubljana, Slovenia, Yugoslavia

Received 20 July 1983; revised 14 September 1983; .

Address for correspondence: Dr P. Rakovec, Topniska 43, 61113 Ljubljana, Yugoslavia.

Abstract

The electrophysiological effects of intravenously administered ethmozin (I mg kg–1) on sinus node function were examined in 32 patients. Based on their clinical data and the results of the initial study, patients were subdivided into group A (n = 12), those with sick sinus syndrome and sinus node recovery time (SNR T) < 1500ms, and group B (n = 20), those without overt sinus node dysfunction and a normal SNRT. The mean sinus cycle length did not change significantly in either group after ethmozin. SNRT was prolonged by ethmozin in group A whereas in group B the increase of SNRT was not significant. Corrected SNRT increased after ethmozin in both subgroups but with a much more pronounced increase in group A. Sinoalrial conduction lime was not significantly changed in any group.

The lengthening of SNRT in the majority of patients with sick sinus syndrome implies that ethmozin might prolong post-tachycardia pauses in these patients. This drug should therefore be administered cautiously to persons with signs indicative of dysfunction of the sinus node.

Key Words: Antiarrhythmic agents • sick sinus syndrome • cardiac electrophysiology


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