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European Heart Journal 1984 5(4):308-316;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

Effects of felodipine on systemic and coronary haemodynamics in patients with angina pectoris

H. EMANUELSSON, Å. HJALMARSON, S. HOLMBERG and F. WAAGSTEIN

Department of Medicine I, Sahlgrenska Hospital, University of Göteborg Göteborg, Sweden

Received 18 April 1983; revised 1 November 1983; .

Address for correspondence: Dr Håkan Emanuelsson, Department of Medicine I, Sahlgrenska Hospital. University of GSteborg, S-413 45 Goteborg, Sweden.

Abstract

In order to study the systemic and coronary haemodynamic effects of felodipine, a new dihydropyridine derivative, 10 patients with coronary artery disease were studied during cardiac catheterizalion. Measurements were performed at rest and during pacing-induced angina pectoris. At rest, the heart rate rose from 70±20 to 78±20 (P<0.05), the systemic arterial pressure decreased by about 20% (P<0–01) and the cardiac index rose from 2.9±l.2 to 4.0±l.0 (P<0.05). The coronary sinus flow (CSF) increased about 50% (P<001). During pacing to the same heart rate as in the control measurements, felodipine induced similar changes in systemic haemodynamic values as in the resting position. Myocardial lactate extraction and ST segment depressipn were not significantly altered. After felodipine, the pacing rate could be further increased in 7 patients as compared with the control value. Both systemic and coronary effects were then very similar compared with those during the lower pacing rale. In conclusion, felodipine is a very potent systemic and coronary vasodilator with potential value in the treatment of hypertension and cardiac failure. The drug may also be of value in the treatment of ischaemic heart disease, but further studies with titratjon of optimal doses are needed in that respect.

Key Words: Angina pectoris • vasodilatation • felodipine • myocardial blood flow


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 ANGIOLOGYHome page
H. Emanuelsson, L. Ekstrom, A. Hjalmarson, C. Jonsteg, and D. Schlossman
Felodipine-Induced Dilatation of Epicardial Coronary Arteries A Randomized, Double-Blind Study
Angiology, January 1, 1986; 37(1): 1 - 7.
[Abstract] [PDF]


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