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European Heart Journal 1984 5(7):529-532;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

Abrupt withdrawal of verapamil in ischaemic heart disease

THE DANISH STUDY GROUP ON VERAPAMIL IN MYOCARDIAL INFARCTION

Received 1 September 1983; revised 19 March 1984; .

Address for correspondence: J. Fischer Hansen, MD, Medical Department II, Kommunehospitalet, Øster Farimagsgade 5, DK-1399 Copenhagen K, Denmark

Abstract

In order to examine the potential hazards of abrupt withdrawal of verapamil 120 mg t.i.d. after six months treatment, a double blind placebo controlled study was designed as part of the Danish multicenter trial of verapamil in acute myocardial infarction. All patients had had a myocardial infarction six months before withdrawal. At the time of withdrawal 30% of the verapamil and 28% of the placebo treated patients were experiencing angina pectoris. At follow-up after two to three weeks 15% of 212 patients in the verapamil treated group and 9% of 260 patients in the placebo treated group reported worsening or reappearance of angina pectoris (P<0.05). One patient in the placebo group developed a myocardial infarction, and one patient in the verapamil group had episodes of supraventricular tachycardia after withdrawal. A ‘withdrawal syndrome’ was not found.

Key Words: Acute myocardial infarction • angina pectoris • calcium antagonist • verapamil


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