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European Heart Journal 1984 5(7):556-560;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

Haemodynamic effects of loud noise in hypertensive patients treated with combined beta-adrenoceptor blockade and precapillary vasodilatation

R. EGGERTSEN, L. ANDRÉN and L. HANSSON

Hypertension Section, Department of Medicine, Östra Hospital, University of Göteborg S-41685 Göteborg Sweden

Received 19 September 1983; revised 15 December 1983; .

Correspondence to Dr L Hansson.

Abstract

The effects of acute exposure to noise on central and regional (calf and forearm) haemodynamics were studied during placebo therapy and during combined nonselective beta-adrenoceptor blockade and precapillary vasodilatation in 9 patients with essential hypertension. On placebo therapy a loud noise (105 dBA for 10 min) caused a significant increase in diastolic and mean arterial pressure due to vasoconstriction. There was also a significant increase of vascular resistance in the calf.

After combined precapillary vasodilatation and non-selective beta-adrenoceptor blockade, the increase in blood pressure during stimulation with noise was not prevented. Thus, systolic as well as diastolic and mean arterial pressures increased significantly. This indicates a temporary resetting of the baroreceptors, allowing a higher level of blood pressure during stimulation with noise.

Such a resetting would involve the central nervous system pathways of the baroreflex and this would explain why the peripherally active therapeutic principle—precapillary vasodilatation and beta-adrenoceptor blockade—was unable to inhibit the blood pressure response induced by noise.

Key Words: Blood pressure • haemodynamics • noise • stress • non-selective beta-adrenoceptor blockade • precapillary vasodilatation • essential hypertension


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