Skip Navigation

European Heart Journal 1984 5(7):561-567;
Copyright © 1984 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PATRASSI, G. M.
Right arrow Articles by GIROLAMI, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PATRASSI, G. M.
Right arrow Articles by GIROLAMI, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1984 The European Society of Cardiology

The contact phase of blood coagulation and renin activation in essential hypertension before and after captopril

G. M. PATRASSI, F. FALLO, S. MARTINELLI, F. MANTERO, G. BOERI and A. GIROLAMI

Institute of Medical Semeiotics, University of Padua Medical School Padua, Italy

Received 27 September 1983; revised 15 February 1984; .

Requests for reprints to: Giovanni M. Patrassi Istituto di Semeiotica Medica, Cattedra di Patologia Medica II, Universitá di Padova, Via Ospedale civile 105, 35100 Padova, Italy

Abstract

The contact phase of blood coagulation in a group of patients suffering from essential hypertension was studied before and after captopril administration. The baseline levels of factor XII, factor XI and plasminogen were significantly higher than in normals and correlated with baseline diastolic blood pressure levels. On the contrary, plasma prekallikrein was not significantly different from normal. These results suggest the presence of a hypercoagulable state in essential hypertension. After captopril administration, factor XII, factor XI and prekallikrein rapidly decreased, perhaps as a consequence of the drug's effect on the vascular endothelial surface. There was no correlation between the changes of active and inactive renin and the changes of prekallikrein and plasminogen levels. Our data do not support the view that factor XII-plasma kallikrein or plasmin dependent pathways are involved in the activation of inactive renin in vivo. Captopril, by provoking rapid pressure changes, appears to be able to affect the clotting system.

Key Words: Contact phase of coagulation • hypertension • captopril • renin and kallikrein interaction


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
G.J. Miller, M.P. Esnouf, A.I. Burgess, J.A. Cooper, and J.P. Mitchell
Risk of Coronary Heart Disease and Activation of Factor XII in Middle-Aged Men
Arterioscler. Thromb. Vasc. Biol., October 1, 1997; 17(10): 2103 - 2106.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.