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European Heart Journal 1984 5(8):668-674;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

The prolonged antihypertensive effect of once daily atenolol: a study of continuous non-invasive arterial blood pressure monitoring

R. ROUDAUT, P. WICKER, F. JUNCA, J. CLEMENTY and M. DALLOCCHIO

Centre Hospitalier et Universitaire de Bordeaux A venue de Magellan, 33604 Bordeaux-Pessac, France

Received 21 November 1983; revised 19 April 1984; .

Address for reprints R. Roudaut, Hôpital Cardiologique, avenue de Magellan, 33604 Pessac, France

Abstract

This study was carried out on 12 hospitalized hypertensive patients to assess the antihypertensive efficiency and the duration of action of a once daily dose of atenolol.

100 mg of atenolol was given at 8 am every day for 5 days. Before and during the therapeutic period, 24-h blood pressure recordings were obtained with a continuous, automatic, non-invasive method working on the principle of oscillometry (Dinamap 845.950). Atenolol induced a significant reduction in mean blood pressure from 119±3.6 to 102.3±4.7 (P<0.001). This effect was significant from the very first day of treatment and was maintained over the duration of the study in ten patients. The decrease in blood pressure induced by atenolol lasted 24 h. Clinical tolerance of atenolol was excellent. In particular no case of excessive bradycardia was noted.

Key Words: Systemic arterial hypertension • once daily regimen • beta-blocking agents


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