Skip Navigation

European Heart Journal 1984 5(9):710-715;
Copyright © 1984 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by CERRI, B.
Right arrow Articles by POLLAVINI, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CERRI, B.
Right arrow Articles by POLLAVINI, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1984 The European Society of Cardiology

Comparative evaluation of the effect of two doses of Nitroderm TTS on exercise-related parameters in patients with angina pectoris

B. CERRI, F. GRASSO, M. CEFIS and G. POLLAVINI

Cardiac Rehabilitation Centre Fasano del Garda, Italy

Received 29 December 1983; .

Address for correspondence: Dr Giorgio Pollavini, viale Romagna, 76.20133 Milano, Italy.

Abstract

The effectiveness of Nitroderm TTS 5 and Nitroderm TTS 10 in stable effort-induced angina pectoris was assessed by measuring the tolerance of 20 selected in-patients to cycloergometric symptom-limited tests During the week preceding the trial previous anti-anginal treatment was gradually withdrawn except for short-acting nitrates. Patients were also familiarized with ergometric laboratory environment.

The trial started with a 24-h control period when placebo was given single-blind to each patient. A double-blind cross-over design was then followed, two groups of 10 patients each being subjected successively to two sequences of therapy. By means of the double-dummy technique, Nitroderm TTS 5 or Nitroderm TTS 10 and matching placebos were applied simultaneously once daily for 24 h on two different days.

Resting heart rate and blood pressure were measured before starting each exercise test, which was performed 3 h after placebo as well as 3 and 24 h after Nitroderm TTS application. The results of the tests were evaluated in terms of maximum workload, duration of exercise and total work performed for each of the two doses administered and compared with the corresponding baseline values.

When compared with placebo both Nitroderm TTS doses produced a significant change (P<0.01) in the assessment variables. After application of the active treatment, duration of exercise, total work performed and maximal workload were increased while lying and standing blood pressures were decreased.

There was no significant difference between the two doses of Nitroderm TTS in the assessment variables, except for systolic blood pressure and lying heart rate 3 and 24 h, respectively, post-dosing.

These results show that after a single application both doses of Nitroderm TTS exert a similar anti-anginal activity by improving effort tolerance for 24 h whereas the haemodynamic effects seem to be more pronounced with the higher dose.

Key Words: Nitroderm TTS • stable angina pectoris


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
R. Thompson
Influence of Transdermal Nitrates on Exercise Capacity in Patients with Stable Angina
Angiology, June 1, 1986; 37(6): 448 - 454.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.