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European Heart Journal 1984 5(9):739-744;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

Isolated systolic hypertension and its relationship to the risk of myocardial infarction, cerebrovascular disease and death in a middle-aged population

J. TUOMILEHTO*, J. T. SALONEN{dagger} and A. NISSINEN*

*Department of Epidemiology, National Public Health Institute Mannerheimintie 166, SF-00280 Helsinki, Finland
{dagger}Department of Community Health, University of Kuopio SF-Box 6, 70211 Kuopio, Finland

Received 23 March 1984; revised 18 June 1984; .

Abstract

The prevalence of hypertension in general and of those complications associated with isolated systolic hypertension (at least 165 mmHg systolic and less than 95 mmHg diastolic pressure) were assessed in a random sample of 3888 men and 4336 women aged 30–59 years at the beginning of the study. The prevalence of isolated systolic hypertension was about 5% both in men and women aged 30 to 49 years; in those aged 50 to 59 years the prevalence was 7% in men and 13% in women. Systolic hypertension was associated with an increased risk of acute myocardial infarction (AMI), cerebrovascular stroke and death both in men and women in the seven-year follow-up period. The relative risk of AMI in men and women with isolated systolic hypertension was 1.65 (P<0.05) and 0.87, respectively, and the relative risk of stroke 0.57 and 1.29, respectively. Isolated systolic hypertension is not uncommon in the middle-aged population and its impact on cardiovascular complications seems to be significant not only on the elderly but also in the middle-aged.

Key Words: Blood pressure • isolated systolic hypertension • hypertension • complications of hypertension • acute myocardial infarction • cerebrovasular disease • epidemiology


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