Skip Navigation

European Heart Journal 1985 6(1):75-84;
Copyright © 1985 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BAGGER, J. P.
Right arrow Articles by NIELSEN, T. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BAGGER, J. P.
Right arrow Articles by NIELSEN, T. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1985 The European Society of Cardiology

Influence of nifedipine on coronary haemodynamics and myocardial metabolism in coronary artery disease

J. P. BAGGER and T. T. NIELSEN

Department of Cardiology, Aarhus Kommunehospital, and Departments of Internal Medicine III, and Clinical Chemistry, Aarhus County Hospital Denmark

Received 8 June 1984; revised 28 September 1984; .

Requests for reprints to: Dr Jens Peder Bagger, Departmen of Cardiology, Aarhus Kommunchospital, 8000 Aarhus C, Denmark

Abstract

The effect of 30 mg sublingual nifedipine on cardiac metabolism and haemodynamics was studied during two identical periods of pacing in 11 patients with chronic coronary artery disease. The pace time to angina pectoris improved after nifedipine in 6 patients, deteriorated in 2 and was unchanged in 3. Nifedipine decreased blood pressure (12%), rate pressure product (10%) and coronary vascular resistance (17%) during pacing. Aorto-coronary sinus (A-Cs) oxygen difference decreased at rest (9%) and postpacing (10%) after nifedipine, although an opposite tendency in coronary sinus blood flow resulted in unchanged myocardial oxygen uptake throughout the study. Although mean myocardial lactate extraction after nifedipine was unchanged during pacing in the whole group of patients, it increased in 9 patients who showed a net lactate release at control pacing (from –50.9±33.5% to –35.9±30.2%, P>0.05). Nifedipine increased free fatty acid (FFA) extraction during pacing (from 1.5±12.9% to 17.4±13.1%, P<0.02) and uptake (from 1.8±8.5 to 11.1±10.6 µmol min–1, P<0.05). Nifedipine influenced only glucose exchange significantly (46% decreased extraction) at 5 min postpacing. The A–Cs citrate gradient lessened 30–40% postpacing after nifedipine administration.

Since the unloading effects of nifedipine did not alter myocardial oxygen uptake, the most important net haemodynamicfinding was the decrease in coronary vascular resistance. Although no significant antianginal effect of a fixed dose of nifedipine was found, the increased uptake of FFA may reflect improved myocardial oxidative metabolism after nifedipine

Key Words: Nifedipine • pacing • angina pectoris • cardiac metabolism • free fatty acids • lactate • glucose • citrate.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.