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European Heart Journal 1985 6(10):840-844;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Timolol maleate and HDL cholesterol after myocardial infarction

T. GUNDERSEN*, J. KJEKSHUS{dagger}, O. STOKKE{ddagger} and T. PEDERSEN§

*Department of Medicine, Division of Cardiology, Aust-Agder Central Hospital Arendal
{dagger}Department of Medicine, Baerum Hospital Oslo, Norway
{ddagger}Institute of Clinical Biochemistry, Rikshospitalet, Oslo University Oslo, Norway
§Department of Medicine, Division of Cardiology, Aker Hospital Oslo, Norway

Received 2 April 1985; revised 2 July 1985; .

Address for correspondenceTorstein Gundersen, M.D., Aust-Agder Central Hospital, 4800 Arendal, Norway.

Abstract

Myocardial infarction, serum lipids, HDL cholesterol, adrenergic betareceptor blockade. The influence of long-term timolol treatment on plasma lipids was analysed in cohorts of the Norwegian timolol multicentre study. The prognostic importance of high-density lipoprotein (HDL) cholesterol concentration after myocardial infarction was also examined. One year timolol treatment was related to a significant reduction in HDL cholesterol levels, from 1.32 mmol l-1 to L26mmoll-1 (P<0.05). After one year the HDL cholesterol levels were significantly lower in the timolol treated patients (1.26 mmol l-1) than in the placebo treated patients (1.32 mmol l-1, P<0.01). However, the HDL cholesterol values after myocardial infarction had no prognostic importance, and in the placebo group total mortality was the same in patients with low HDL cholesterol ( < 1.25mmol l-1) and high HDL cholesterol (> 1.25mmoll-1), respectively 15.0% and 14.8%. Timolol treatment was related to a reduction in mortality both in patients with low (24%, NS) and with high (43%, P < 0.05) HDL cholesterol levels. Thus, any deleterious effects of timolol on serum lipids did not attenuate its protective effect on the damaged myocardium.

Key Words: Myocardial infarction • serum lipids • HDL cholesterol • adrenergic betareceptor blokade


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