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European Heart Journal 1985 6(10):851-857;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Non-invasive assessment of aortic and mitral regurgitation

J. OHLSSON, B. WRANNE and T. MARKLUND*

Departments of Clinical Physiology S-581 85 Linkoping, Sweden
*Radiology, University Hospital S-581 85 Linkoping, Sweden

Received 15 March 1985; revised 21 June 1985; .

Address for correspondence: Jan Ohlsson, M.D., Department of Clinical Physiology, Region Hospital, S-581 85 Linkõping, Sweden.

Abstract

A non-invasive method for the assessment of the degree of regurgitation in aortic and mitral regurgitation is presented. Regurgitant volume was obtained by subtracting effective stroke volume (SVeff), determined with a CO2-rebreathing method, from total stroke volume (SVtot) determined by M-mode echocardiography. Regurgitant volume and a non-invasive regurgitant index (SVtot/SVeff) were compared with semiquantitative angiography in 49 patients [mean age = 62±11 (SD) years], who on the basis of the angiography were allocated to four different groups (no, slight, moderate and severe regurgitation). Eighteen normal subjects [mean age = 26±9 (SD) years], not subjected to angiography, served as a control group and are included in the group without regurgitation. When the cube formula was used for the determination of SVtot, the average regurgitant volumes for the different groups were: 0.5±24 (SD), 15±22, 85±48 and 138±65ml and the corresponding SVtot/SVeff ratios were: 1.0±0.3, l.2±0.3, 2.4±0.8 and 3.8± 1.5, respectively. There were significant differences (P<0.01) between the groups with slight, moderate and severe regurgitation respectively both for regurgitant volume and regurgitant index, but no significant difference between the group with slight regurgitation and the group without regurgitation. This study suggests that the severity of aortic and mitral regurgitation can be estimated non-invasively by the combined use of a CO2-rebreathing method and echocardiography.

Key Words: Valve regurgitation • non-invasive • echocardiography • rebreathing • angiography


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