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European Heart Journal 1985 6(2):109-113;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Arrhythmias with brief, high-dose intravenous streptokinase infusion in acute myocardial infarction

B. CERCEK and M. HORVAT

Centre for Intensive Internal Medicine, University Clinical Centre Ljubljana 61105 Ljubljana, Zaloska 7, Yugoslavia

Received 6 June 1984; revised 14 November 1984; .

Asist. mag. Bojan Cercek, Centre for Intensive Internal Medicine. University Clinical Centre, 61105 Ljubljana. Zaloska 7. Yugoslavia.

Abstract

Cardiac arrhythmias are described during the first 2 h after brief, high-dose, intravenous streptokinase infusion in 23 patients with evolving myocardial infarction was given. A control group consisted of 22 similar patients with acute myocardial infarction not treated with streptok inase infusion. On the basis of an early peak of creatine kinase activity successful reperfusion was achieved in 60.9% of patients. Significantly more ventricular premature complexes (P<0.01) and paroxysms of idioventricular rhythm (P<0.05) were noticed in the treated group. Premature ventricular complexes did not predict any severe ventricular arrhythmia. Accelerated idioventricular rhythm appears to be the most specific arrhythmia encountered with thrombolytic therapy of acute myocardial infarction. We propose that in routine clinical work it can be used as a bedside sign ofsuccessful reperfusion.

Key Words: Arrhythmias • myocardial infarction • streptokinase • reperfusion


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