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European Heart Journal 1985 6(2):158-167;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Regulation of lipases involved in the supply of substrate fatty acids for the heart

H. STAM and W. C. HÜLSMANN

Department of Biochemistry I, Medical Faculty, Erasmus University Rotterdam P.O. Box 1738, 3000 DR Rotterdam, The Netherlands

Received 1 February 1984; .

Requests for reprints to: Dr H. Stam, Department of Biochemistry I, Medical Faculty, Erasmus University Rotterdam, PO Box 1738,3000 Rotterdam, The Netherlands.

Abstract

Evidence is presented that all lipase activities present in the vascular and myocardial tissue from rat heart are regulated by product inhibition. Lipoprotein lipase activity, which plays arole in the uptake of circulating triglycerides, is determined by its reaction products, e.g. fatty acids and, predominantly, monoglycerides. Tissue acid and neutral lipase activities are regulated by product fatty acids and their coenzyme A (CoA) and carnitine ester derivatives. The order of potency is palmitoyl CoA > palmitoyl carnitine > palmitate for neutral lipase and palmitoyl carnitine > palmitoyl CoA > palmitate for acid lipase activity. Product inhibition of extracellular and intracellular lipolytic processes warrants a close couplingbetween the supply of substrate fatty acids and the rate of fatty acid oxidation as determinedby cardiac contractile activity. None of the lipases studied was directly affected by catabolic hormones (norepinephrine, glucagon) or their intracellular second messengers (cyclic AMP, protein kinase, Ca2+, calmodulin).

Key Words: Myocardial lipases, • lipolysis, • free fatty acids, • detergents.


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