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European Heart Journal 1985 6(3):190-198;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Very early intervention with metoprolol in suspected acute myocardial infarction

K. S. SALATHIA*, J. M. BARBER*, E. L. MCILMOYLEI{dagger}, J. NICHOLAS*, A. E. EVANS{dagger}, J. H. ELWOOD{dagger}, G. CRAN{ddagger}, R. G. SHANKS§ and D. MCC. BOYLE*,

*Cardiac Department, Ulster Hospital Dundonald Belfast
{dagger}Departments of Community Medicine, Queens University Belfast
{ddagger}Applied Mathematics Queens University Belfast
§Therapeutics and Pharmacology, Queens University Belfast

Received 19 September 1984; revised 20 November 1984; .

Address for correspondence:Dr D. McC. Boyle, Cardiac Department, Ulster Hospital, Dundonald, Belfast

Abstract

A double blind randomized study of 800 patients was carried out to determine if very early intervention with metoprolol (15 mg I. V. followed by oral administration) in suspected acute myocardial infarction affected overall mortality in selected subgroups, (age, site of infarct, delay to intervention). Sudden death occurred less frequently in patients allocated to metoprolol but there was no significant difference in total mortality on discharge, at three months andat twelve months. Ventricular fibrillation after intervention was not significantly reduced. Adverse reactions did not occur significantly more frequently in patients assigned to metoprolol.

Key Words: Myocardial infarction • beta adrenergic blockade • metoprolol • mortality • sudden death


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