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European Heart Journal 1985 6(4):349-357;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Effect of long-term oral nifedipine therapy on left ventricular regional wall function at rest and during supine bicycle exercise

R. J. BOS, P. W. SERRUYS, R. W. BROWER, H. J. TEN KATEN, G. VANHALEWEYK and P. G. HUGENHOLTZ

Catheterization Laboratory, Thoraxcenter, Erasmus University Hospital Rotterdam, The Netherlands

Received 13 August 1984; revised 2 January 1985; .

Patrick W. Serruys, MD, Catheterization Laboratory, Thoraxcenter, Erasmus University, Dr Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.

Abstract

15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug. Haemodynamic variables were monitored as was epicardial marker motion, using biplane cineradiography during exercise, the markers having been implanted at the time of surgery. We found significant (P<0.001) reductions in end-diastolic and end-systolic regional dimensions at maximal exercise after oral nifedipine, associated with a significant reduction in exertional angina, which persisted during long-term treatment. No adverse effects of the drug were observed.

Key Words: Nifedipine • exercise testing • wall motion


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