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European Heart Journal 1985 6(6):468-472;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Plasma concentrations of platelet-specific proteins and serum thromboxane B2 production in response to treatment with dipyridamole. A pilot study of 27 post-myocardial infarction patients

S. SAFAI-KUTTI, J. KUTTI, A. VEDIN and C. WILHELMSSON

Dèpartment of Medicine, Östra Hospital, University of Göteborg Göteborg, Sweden

Received 16 October 1984; revised 21 February 1985; .

Dr J. Kutti, Department of Medicine, Östra Hospital, 416 85 Göteborg, Sweden.

Abstract

In the present study 27 post-myocardial infarction patients were treated with Persantin capsules (Depot-Kapseln, sustained release form), containing 200 mg dipyridamole, b.i.d. over a period of 3 weeks. Baseline levels for plasma beta-thromboglobulin (BTG), platelet factor 4 (PF4), and serum thromboxane B2 (TXB2) were obtained on day 0 and subsequently on days 1, 3, 5, 7,14 and 21. The baseline levels for plasma BTG and PF4 as well as for serum TXB2 significantly exceeded those for a control group consisting of healthy subjects. The plasma values for BTG and PF4 remained unchanged during the whole study period. During the first week of study the levels for serum. TXB2 were unchanged; however, on days 14 and 21 the means for TXB2 dropped significantly. There is experimental work to suggest that dipyridamole may exert an inhibitory effect on platelet thromboxane biosynthesis. The present results support this concept.

Key Words: Dipyridamole • beta-thromboglobulin • platelet factor 4 • thromboxane B2 • coronary artery disease


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