Copyright © 1985 by the European Society of Cardiology.
© 1985 The European Society of Cardiology
Prognosis of patients with different peak serum creatine kinase levels after first myocardial infarction
Divisione di Cardiologia, Ospedale S. Giovanni Torino, Italy
The Interuniversity Cardiology Institute Rotterdam, The Netherlands
The Thoraxcenter, Erasmus University and University Hospital ‘Dijkzigt’ Rotterdam, The Netherlands
Received 17 December 1984; revised 18 March 1985; .
Paolo Fioretti, MD, Thoraxcenter, University Hospital ‘Dijkzigt’, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Abstract
The extent to which patients with low peak serum creatine kinase (CK) at their first myocardial infarction differ from patients with high CK levels in terms of risk for subsequent ischaemic events was investigated in 266 patients who survived the first 48 h from the onset of infarction. All patients were followed up for one year. Four groups were formed based on peak CK
200, 201–400, 401–800 and >800 IU l-1. During follow-up the incidence of mortality was 15% (N=39), non-fatal re-infarction 9% (N=23), and angina 53% (N=140). Hospital mortality was significantly higher (P<0.02) in the highest CK-group (16%), but the incidence of non-fatal re-infarction, angina pectoris and late mortality was similar in the four groups. In hospital survivors, ischaemic ST-changes during pre-discharge symptom limited bicycle stress test and multiple vessel disease were equally distributed in all four groups.
We conclude that while hospital mortality is directly related to peak CK, there is no relationship between peak CK and late mortality, non-fatal re-infarctions, or recurrent angina. Accordingly, diagnostic and therapeutic procedures in the individual patients are notinfluenced by the amount of serum CK released during acute infarction.
Key Words: Myocardial infarction • serum creatine kinase
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K.-H. Mak, K.-S. Chia, J.D. Kark, T. Chua, C. Tan, B.-H. Foong, Y.-L. Lim, and S.-K. Chew Ethnic differences in acute myocardial infarction in Singapore Eur. Heart J., January 2, 2003; 24(2): 151 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Savonitto, C. B. Granger, D. Ardissino, L. Gardner, C. Cavallini, M. Galvani, F. Ottani, H. D. White, P. W. Armstrong, E. M. Ohman, et al. The prognostic value of creatine kinase elevations extends across the whole spectrum of acute coronary syndromes J. Am. Coll. Cardiol., January 2, 2002; 39(1): 22 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Alexander, R. A. Sparapani, K. W. Mahaffey, J. W. Deckers, L. K. Newby, E. M. Ohman, R. Corbalan, S. L. Chierchia, J. B. Boland, M. L. Simoons, et al. Association Between Minor Elevations of Creatine Kinase-MB Level and Mortality in Patients With Acute Coronary Syndromes Without ST-Segment Elevation JAMA, January 19, 2000; 283(3): 347 - 353. [Abstract] [Full Text] [PDF]
|
|