Skip Navigation

European Heart Journal 1985 6(8):681-688;
Copyright © 1985 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by CLELAND, J. G. F.
Right arrow Articles by MORTON, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CLELAND, J. G. F.
Right arrow Articles by MORTON, J. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1985 The European Society of Cardiology

Total body and serum electrolyte composition in heart failure: the effects of captopril

J. G. F. CLELAND*,, H. J. DARGIE*, B. W. EAST{dagger}, I. ROBERTSON{dagger}, G. P. HODSMAN{dagger}, S. G. BALL{dagger}, G. GlLLEN§, J. I. S. ROBERTSON{dagger} and J. J. MORTON{dagger}

*Department of Cardiology Western Infirmary, Glasgow G11 6NT, U.K
{dagger}Scottish Universities Research & Reactor Centre East Kilbride, U.K
{ddagger}MRC Blood Pressure Unit Western Infirmary, Glasgow Gil 6 NT, U.K
§Department of Clinical Physics West Graham Street, Glasgow G2, U.K

Received 7 December 1984; revised 22 April 1985; .

Address for correspondence: Dr J. G. F. Cleland, Department of Cardiology, Western Infirmary, Glasgow G11 6NT, Scotland

Abstract

We compared the long-term effects of captopril and placebo on patients with heart failure in a double blind crossover fashion. Serum and total body elecrolytes were measured and the response to 6 week periods of treatment with captopril determined. During the placebo phase of the study, total body potassium was low at 92±14% of predicted normal (P<0.05) and total body sodium was high at 104+7% of predicted normal (P<0.05). Total body chlorine did not differ from predicted normal (99+12%). In those patients with active plasma renin concentrations above the normal range (greater than 50 µU ml–1) total body potassium was even more markedly deplete (85+13% of predicted normal). This group was also characterized by lower serum potassium and sodium concentrations and lower blood pressure.

Total body potassium increased significantly on captopril, and the rise was greatest in those with the highest plasma renin concentrations during the placebo phase of the study. However, captopril had no significant effect on total body sodium and chlorine or weight indicating that no long-term natriuresis had occurred.

Key Words: Captopril • heart failure • body electrolyte composition


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
J. E. Macdonald and A. D. Struthers
What is the optimal serum potassium level in cardiovascular patients?
J. Am. Coll. Cardiol., January 21, 2004; 43(2): 155 - 161.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
P. R. Marantz, M. H. Alderman, and J. N. Tobin
Diagnostic Heterogeneity in Clinical Trials for Congestive Heart Failure
Ann Intern Med, July 1, 1988; 109(1): 55 - 61.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.