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European Heart Journal 1985 6(8):695-701;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Mioflazine, a potentially protective drug against ischaemic damage: A study in dogs

A. J. WOOD*, K. ISTED{dagger}, J. HYND{dagger}, M. J. MAIN{ddagger}, M. I. M. NOBLE§, J. PARKER{dagger} and A. J. DRAKE-HOLLAND{ddagger},

{dagger}Department of Cardiology, St George's Hospital London SW170QT
{ddagger}Department of Medicine 1, St. Georges’s Hospital Medical School London SW17 0RE
§King Edward VII Hospital Midhurst Sussex GU29 0BL, U.K.

Received 20 November 1984; revised 21 March 1985; .

Address for correspondence: Dr A. J. Drake-Holland, Department of Medicine 1, St. Georges's Hospital Medical School, London SW17 ORE, England.

Abstract

The protective effect of intravenous mioflazinepretreatment was examined in intact dogs on cardiopulmonary bypass. The mechanical function of the left ventricle was measured by isovolumic pressure—volume relationships. Mioflazine alone had no inotropic effect. After one hour of normothermic (37°C) global ischaemia of the whole heart, no control hearts, pretreated with solvent, recovered sufficiently to support the animal‘s circulation; this was not the case with animals pretreated with mioflazine, they all survived. After the 30-min reperfusion period, the solvent (control) pretreated hearts had a significantly lower (P=0.05) systolic and higher (P = 0.001) diastolic pressure-volume curve than those given mioflazine.

Key Words: Myocardial ischaemia • protective drugs • cardio-pulmonary bypass


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