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European Heart Journal 1985 6(8):702-705;
Copyright © 1985 by the European Society of Cardiology.
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© 1985 The European Society of Cardiology

Nifedipine and alpha1-adrenergic blockade in Raynaud‘s phenomenon

A. KAHAN*, J. M. FOULT{dagger}, S. WEBER{dagger}, B. AMOR*, C. J. MENKES* and M. DEGEORGES{dagger}

*Departments of Rheumatology 27, rue du faubourg Saint Jacques, 75674 Paris Cedex 14, France
{dagger}Departments of Cardiology, Hôpital Cochin 27, rue du faubourg Saint Jacques, 75674 Paris Cedex 14, France

Received 10 August 1984; revised 14 May 1985; .

Address for correspondence André Kahan, MD, Service de Rhumatologie, Hôpital Cochin, 27, rue du faubourg Saint Jacques 75674 Pans Cedex 14, France.

Abstract

The efficacy of nifedipine and prazosin in the treatment of Raynaud's phenomenon was assessed in a prospective double-blind randomized cross-over trial in 15 patients. Each patient received one week of nifedipine 20 mg TID, one week of prazosin 1 mg TID, and 2 weeks of placebo. Nifedipine was shown to be effective in reducing both the frequency and the severity of Raynaud's phenomenon, whereas prazosin was ineffective. Before initiation of therapy in the 15 patients, pressor responses to the intravenous alpha1-agonist phenylephrine were assessed in the basal state, 30 min after 20 mg oral nifedipine, and 30 min after 1 mg oral prazosin; the shift to the right of the log dose-vasopressor response curves to phenylephrine was similar with nifedipine and prazosin.

Key Words: Calcium antagonist • prazosin • alpha1-adrenergic antagonist


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