Copyright © 1986 by the European Society of Cardiology.
© 1986 The European Society of Cardiology
In vitro validation of a new cardiac catheter technique for recording monophasic action potentials
Cardiology Division and Department of Biomedical Engineering of The Johns Hopkins Medical Institutions, and the Cardiovascular Section of the National Institute on Aging, Gerontology Research Center, National Institutes of Health Baltimore, Maryland, U.S.A.
Received 15 May 1985; revised 9 August 1985; .
Dr M. R. Franz, Cardiology Division, Stanford University Medical Center, Stanford, CA 94305, U.S.A.
Abstract
Monophasic action potential (MAP) recording with non-suction, ‘contact’ electrode catheters has been shown possible and safe during clinical catheterization, but direct validation of this new technique is lacking. We therefore recorded these contact electrode MAPs simultaneously with transmembrane action potentials (TAPs) from closely adjacent sites in perfused and superfused rabbit septum preparations and performed a quantitative comparison between the two signals for duration and area at 30, 60 and 90% repolarization. To obtain a variety of action potential durations and configurations for the comparison, the rate and rhythm of stimulation and the extracellular calcium or potassium ion concentration were changed. With action potential duration at 90% repolarization made to vary from 150 to 513 ms, the mean absolute difference ±SD between the simultaneous intra- and extracellular recordings was 5.4±11.3 ms and the linear correlation coefficient was r = 0.96 ± 0.03. Similar agreement between the two types of recordings was found for measurements for area and at 60 and 30% repolarization levels. These data confirm that MAPs recorded with this clinically safe contact electrode technique can be used to measure accurately the repolarization time course of transmembrane action potentials.
Key Words: Monophasic action potentials • contact electrode • action potential duration • action potential area
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