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European Heart Journal 1986 7(1):47-53;
Copyright © 1986 by the European Society of Cardiology.
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© 1986 The European Society of Cardiology

Effect of sotalol, aprindine and the combination aprindine—sotalol on monophasic action potential duration

R. STROOBANDT*,, J. BRACHMANN{dagger}, H. KESTELOOT{ddagger}, W. KÜBLER{dagger} and J. SENGES{dagger}

*Department of Cardiology, St.-Jozef Hospital Oostende, Belgium
{dagger}Abteilung Innere Medizin III (Kardiologie), Medizinische Universitätsklinik Heidelberg, F.R.G.
{ddagger}Department of Cardiology the St.-Rafael University Hospital Leuven, Belgium

Received 18 March 1985; revised 19 August 1985; .

R. Stroobandt, MD, Dept. Cardiology, St.-Jozef Hospital, B-8400 Oostende, Belgium

Abstract

The effects of sotalol, aprindine and the combination aprindine-sotalol in the intact dog heart were evaluated during constant atrial pacing with the use of monophasic action potential (MAP) recording. A first group of five dogs was given 1.5 mg kg–1 body weight of sotalol, followed by a second infusion of 1.5 mg kg–1 30 min later. Both doses of sotalol produced a statistically significant increase in right atrial MAP duration at 50% of repolarization (RAMAP50) and right ventricular MAP duration at 90% of repolarization (RVMAP90). To a second group of six dogs aprindine 1 mg kg–1 and aprindine 2 mg kg–1 were administered intravenously. The infusion of aprindine did not alter right atrial and right ventricular MAP duration. The addition of 1.5 mg kg–1 of sotalol to the dogs pretreated with aprindine 2 mg kg–1 resulted a 25% increase in RAMAP50 and a 21% prolongation of RVMAP90. In summary, sotalol lengthens atrial and ventricular monophasic action potential duration and still prolongs repolarization of monophasic action potentials after previous administration of aprindine. A combination of sotalol, a beta-adrenergic blocker possessing class III efficacy, with a class I antiarrhythmic agent may be useful with respect to their electrophysiological action.

Key Words: Sotalol • aprindine • monophasic action potentials • antiarrhythmic drugs


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