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European Heart Journal 1986 7(1):54-60;
Copyright © 1986 by the European Society of Cardiology.
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© 1986 The European Society of Cardiology

Felodipine in ventricular dysfunction

A. C. TWEDDEL and I. HUTTON

University Department of Medical Cardiology, Royal Infirmary Glasgow, U.K.

Received 8 May 1985; revised 25 July 1985; .

Dr I. Hutton, Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, Scotland.

Abstract

The systemic and coronary haemodynamic effects of felodipine were evaluated at rest and during stress induced atrial pacing in fourteen patients with chronic cardiac failure, secondary to coronary heart disease. Felodipine was an effective arteriolar vasodilator producing increases in cardiac index from 2.6 ± 0.l to 3.5 ± 0.2 l min–1 m–2 (P<0.001) and stroke volume 35.3 ± 2.7 to 41.4 ± 2.4 ml beat–1 m–2 (P<0.002).

Coronary venous flow also increased significantly (126 ± 8 to 168 ± 13 ml min–1) (P<0.005) and this did not appear to be accompanied by an increase in myocardial oxygen usage, as myocardial oxygen consumption was essentially unchanged. When the myocardium was stressed by atrial pacing the increase in cardiac output and stroke volume was maintained—25% and 23%, respectively (P<0.01). These results suggest that felodipine may well have a significant role in the management of patients with congestive cardiac failure.


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