Copyright © 1986 by the European Society of Cardiology.
© 1986 The European Society of Cardiology
The effect of isosorbide-5-mononitrate (5-ISMN) Durules® on exercise tolerance in patients with exertional angina pectoris. A placebo controlled study
*Department of Medicine, Östra Hospital S-416 85 Göteborg
Department of Clinical Physiology Södersjukhuset, S-100 64 Stockholm
Department of Medicine, Danderyd Hospital S-182 88 Danderyd
Department of Medicine, Karolinska Hospital S-104 01 Stockholm, Sweden
¶Department of Clinical Physiology, Karolinska Hospital S-104 01 Stockholm, Sweden
revised 18 March 1986; accepted 23 December 1985.
Abstract
Twenty-four patients with stable exercise-induced angina pectoris entered a double-blind cross-over study. Isosorbide-5-mononitrate (5-ISMN) 60 mg in a controlled release formulation (Durules®) given once daily was compared with identical placebo. The exercise tolerance was determined by bicycle ergometry before and 3 h after a single dose of 5-ISMN and following one week's treatment with 5-ISMN and placebo. Nineteen patients completed the study. Exercise tolerance until the onset of chest pain and until 1 mm ST segment depression increased significantly 3 h after dose. The same increase was seen both after a single dose and the same dose under steady-state conditions. No increase was seen with placebo. The heart rate and systolic blood pressure reactions in the standing position were less pronounced 3 h after dose in steady-state than after a single dose of 5-ISMN. Headache was the only bothersome side-effect reported. The study demonstrates that 60 mg 5-ISMN in a Durules® formulation given once daily has a significant anti-anginal effect and that tolerance does not develop.
Key Words: Exercise testing • angina pectoris • 5-ISMN in Durules® formulation
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Stahle, E. Mattsson, L. Ryden, A.-L. Unden, and R. Nordlander Improved physical fitness and quality of life following training of elderly patients after acute coronary events. A 1 year follow-up randomized controlled study Eur. Heart J., October 2, 1999; 20(20): 1475 - 1484. [Abstract] [PDF]
|
|
|
|
 |
|
 M. G. Niemeyer, H. A. J. Kleinjans, R. de Ree, A. H. Zwinderman, T. J. M. Cleophas, E. E. van der Wall, A.J.M. Cleophas, and Dutch Mononitrate Quality of Life Study Group Comparison of Multiple-Dose and Once-Daily Nitrate Therapy in 1212 Patients with Stable Angina Pectoris: Effects on Quality of Life Indices Angiology, October 1, 1997; 48(10): 855 - 862. [Abstract] [PDF]
|
|
|
|
|
|
T. J. M. Cleophas, M. G. Niemeyer, E. E. van der Wall, and J. van der Meulen Nitrate-Induced Headache in Patients with Stable Angina Pectoris: Beneficial Effect of Starting on a Low Dosage Angiology, July 1, 1996; 47(7): 679 - 685. [Abstract] [PDF]
|
|