Copyright © 1986 by the European Society of Cardiology.
© 1986 The European Society of Cardiology
Efficacy of incremental doses of tiapamil on exercise performance in patients with chronic stable angina pectoris
Department of Cardiology, St Bartholomew's Hospital London EC1A 7BE, U.K.
revised 7 April 1986; accepted 15 February 1985.
Address for correspondence: Dr J. C. O'Keefe, Department of Cardiology, Princess Alexandra Hospital, Ipswich Road, Q4102, Australia.
Abstract
Ten patients with chronic stable angina were treated with 4 incremental doses of tiapamil (200 mg, 400 mg, 600 mg and 800 mg) in a double-blind, placebo-controlled study. Treadmill exercise electrocardiograms were performed before and after single oral doses of tiapamil. A dose-dependent increase in exercise duration occurred after tiapamil with significant improvement after tiapamil 600 mg amd 800 mg. Mean exercise duration increased from 327±41 seconds (control) to 399±49 seconds (P<0.01) after tiapamil 600 mg and from 314±39 seconds (control) to 416±49 seconds after tiapamil 800 mg, P<0.001. There was an associated improvement in mean exercise time to onset of I mm ST-segment depression from 240±41 seconds (control) to 300±48 seconds in 10 patients after tiapamil 600 mg, (P<0.02) and from 206±35 seconds (control) to 272±51 seconds in 9 patients after tiapamil 800 mg, P<0.01. Two patients were free of angina and 1 patient normalized his ST-segments after tiapamil 800 mg. Dose-dependent side-effects were mild and tolerable. Tiapamil is safe and highly effective in improving exercise tolerance and relieving myocardial ischaemia in patients with chronic stable angina.
Key Words: Calcium antagonist drugs • angina • exercise test