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European Heart Journal 1986 7(10):893-897;
Copyright © 1986 by the European Society of Cardiology.
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© 1986 The European Society of Cardiology

Felodipine as a replacement for minoxidil in the treatment of severe hypertension

C. G. WATHEN, D. MACLEOD, L. TUCKER and A. L. MUIR

Department of Medicine, Royal Infirmary Edinburgh EH3 9YW, U.K.

revised 1 April 1986; accepted 21 February 1986.

Address for correspondence: Dr C. G. Wathen, Department of Medicine, Royal Infirmary, Edinburgh EH3 9YW, Scotland.

Abstract

The new calcium antagonist felodipine has been compared with minoxidil in the management of severe hypertension in a group of 17 men. Satisfactory control of blood pressure was achieved in all patients with a combination of beta blocker, loop diuretic and minoxidil after inadequate control on a standard regimen of beta blocker, thiazide and vasodilator. The optimal dose of felodipine was titrated after a placebo phase. In a double blind crossover trial blood pressure on felodipine (150/88±19/8 mmHg, SD) was the same as on minoxidil (148/87±23/11 mmHg, NS) and the postural difference was similar (NS) on both drug regimens. Body weight was lower on the felodipine regimen (P<0.01), as was supine heart rate (P<0.05). There was a small rise in plasma liver enzymes on felodipine therapy (P<0.01). Felodipine was well tolerated and may be useful in the management of severe hypertension.

Key Words: Felodipine • minoxidil • severe hypertension


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