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European Heart Journal 1986 7(2):146-149;
Copyright © 1986 by the European Society of Cardiology.
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© 1986 The European Society of Cardiology

Haemodynamic effects of pharmacological doses of secretin in patients with impaired left ventricular function

P. GUNNES and K. RASMUSSEN

Section of Cardiology, Department of Medicine, University Hospital of Tromso Norway

Received 19 March 1985; revised 9 September 1985; .

Address for correspondence: P. Gunnes, Section of Cardiology, Department of Medicine, University Hospital of Tromso, N-9012 Tromso, Norway.

Abstract

The haemodynamic effects of secretin 4 CU/kg·h was studied in seven patients with impaired left ventricular function. Cardiac output (P<0.01) and stroke volume (P<0.05) increased persistently during the infusion period, whereas the total systemic resistance fell (P<0.01). Heart rate increased slightly (P<0.01). The systemic arterial pressure was unchanged except for a small, transient reduction at the onset of the infusion (P<0.01). The pulmonary capillary wedge pressure, the pulmonary artery pressure and the pulmonary arteriolar resistance were unaltered. In patients with depressed cardiac function, pharmacological doses of secretin increased left ventricular performance by means of arteriolar dilation and a positive inotropic effect is also suggested.

Key Words: Cardiac output • heart failure • inotropic drugs • vasodilators • secretin


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