Skip Navigation

European Heart Journal 1986 7(3):227-233;
Copyright © 1986 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by REIKERAS, O.
Right arrow Articles by MJØS, O. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by REIKERAS, O.
Right arrow Articles by MJØS, O. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1986 The European Society of Cardiology

Haemodynamic effects of insulin and beta receptor blockade during acute left ventricular failure in dogs

O. REIKERAS*,, P. GUNNES{dagger}, D. SØRUE*, R. EKROTH{ddagger} and O. D. MJØS§

*Cardiovascular Section, Surgical Department Institute of Clinical Medicine, University of Tromsø Norway
{dagger}Section of Cardiology, Medical Department, Institute of Clinical Medicine, University of Tromsø Norway
{ddagger}Department of Cardiothoracic Surgery, Sahlgrenska Hospital, University of Gothenburg Sweden
§Department of Physiology, Institute of Medical Biology, University of Tromsø Norway

Received 29 May 1985; revised 8 October 1985; .

Address for correspondence: Olav Reikeras, Tromsø University Hospital, N-9012 Tromsø, Norway

Abstract

Acute ischaemic heart failure was induced in 13 dogs by coronary embolisation. Severe dysfunction of the left ventricular (LV) performance was shown by a significant increase in LV end-diastolic pressure and significant decreases in maximum rate of LV pressure rise (LVdP/dtmax), stroke volume and cardiac output. 300 IU of fast-acting insulin was injected as a bolus dose in 7 dogs 90 min after the embolisation procedure. This was followed by infusion of glucose and potassium to maintain normal blood levels. After 15 min, insulin had significantly improved the performance of the failing left ventricle. Total peripheral resistance was decreased. Myocardial blood flow was significantly increased while myocardial oxygen consumption was unchanged. After beta receptor blockade with propranolol 0.5 mg kg–1 given intravenously, the improvement in cardiac performance was reduced, heart rate decreased, and a concomitant decrease in myocardial blood flow and oxygen consumption was recorded. Compared with values before treatment, the net effect of combined insulin and beta receptor blockade was unchanged LVdP/dtmax, LV end-diastolic pressure and cardiac output, significantly increased stroke volume and decreased heart rate, and moderately reduced total peripheral resistance and mean aortic blood pressure. Myocardial blood flow was unaltered, while myocardial oxygen consumption was significantly reduced. In the control group of 6 dogs propranolol was given before insulin, and similar haemodynamic alterations were found.

Key Words: Beta receptor blockade • haemodynamics • heart failure • insulin • myocardial ischaemia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.