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European Heart Journal 1986 7(8):693-696;
Copyright © 1986 by the European Society of Cardiology.
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© 1986 The European Society of Cardiology

Increased plasma levels of atrial natriuretic peptide in patients with congestive heart failure

A. PETTERSSON*,, J. HEDNER{dagger}, T. HEDNER{dagger}, P. HELD{ddagger}, K. SWEDBERG{ddagger} and A.C. TOWLE§

*Departments of Pharmacology Goteborg, Sweden
{dagger}Departments ofClinical Pharmacology Goteborg, Sweden
{ddagger}Departments ofMedicine, Sahlgrenska and Östra Hospitals, University of Göteborg Goteborg, Sweden
§Departments of Biological Research Center, University of North Carolina North Carolina, U.S.A.

revised 18 February 1986; accepted 16 September 1985.

Address for correspondenceDr Anders Pettersson, Department of Pharmacology, University of Göteborg, Box 33031, S-400 33 Göteborg, Sweden.

Abstract

Atrial natriuretic peptide (ANP) is a recently discovered hormone, originating from atrial myocardium. The peptide (or family of peptides) induces potent diuretic/natiuretic, vasorelaxing and aldosterone inhibitory effects. We have investigated plasma concentrations of immunoreactive ANP in 10 patients with congestive heart failure (CHF). Mean plasma ANP concentrations were more than three times higher in CHF patients than in a matched control group. High plasma ANP concentrations in pathophysiological conditions with a high preload combined with salt and water retention is consistent with a physiological role of this hormone to correct hypervolemia by causing natriuresis and diuresis. It is concluded that ANP homeostasis is altered in patients with CHF and that this hormone may be of importance in the pathophysiology of CHF.

Key Words: Congestive heart failure • atrial natriuretic peptide • diuresis/natriuresis • aldosterone


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