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European Heart Journal 1986 7(9):749-759;
Copyright © 1986 by the European Society of Cardiology.
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© 1986 The European Society of Cardiology

International Mexiletine and Placebo Antiarrhythmic Coronary Trial (IMPACT): II. Results from 24-hour electrocardiograms

IMPACT RESEARCH GFROUP*,

revised 18 February 1986; accepted 25 September 1985.

Address for correspondence in North America: IMPACT Coordinating Center, Maryland Medical Research Institute, 500 Wyndhurst Avenue, Baltimore, MD 21210, U.S.A.

Abstract

The sustained release form of mexiletine (Mexitil–Perlongets), 360 mg b.i.d., was evaluated for antiarrhythmic efficacy in a double-blind placebo trial in 630 patients with recent documented myocardial infarction. The drug was effective in reducing the occurrence of complex forms of ventricular arrhythmias as well as frequent premature ventricular complexes during the first four months of treatment. In addition, a favourable trend antiarrhythmic efficacy of the drug was observed after 12 months of treatment, but this was not statistically significant. The data from this study suggest that mexiletine was as effective in preventing the occurrence of frequent or complex cardiac arrhythmias as in reducing such arrhythmias present during the first four months following acute myocardial infarction. Mortality was higher in the mexiletine group (7.6%) than in the placebo group (4.8%), although the difference was not statistically significant.

Key Words: Mexiletine • antiarrhythmic trial • ambulatory electrocardiograms


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