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European Heart Journal 1987 8(12):1340-1345;
Copyright © 1987 by the European Society of Cardiology.
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© 1987 The European Society of Cardiology

Effects of quinidine on ventricular repolarization

J. BRUGADA, A. SASSINE, D. ESCANDE, C. MASSE and P. PUECH

Laboratoire de Physiologie I, Institut de Biologie Boulevard Henri IV 34060 Montpellier Cedex, France

Received 31 October 1986; revised 12 May 1987; .

J. Brugada, Laboratoire de Physiologie I. Institut de Biologie, Boulevard Henri IV, 34060 Montpellier, France.

The possibility that an asynchronous increase in the ventricular monophasic action potential duration is the basis of the quinidine-induced torsade de pointes, has led us to study the electrophysiological effects of increasing doses of intravenous quinidine. We measured the monophasic action potential duration and the ventricular effective refractory period at several right ventricular myocardial sites in the anaesthetized dog.Our results showed that quinidine induces a dose-dependent prolongation in ventricular effective refractory period and in ventricular monophasic action potential duration. These increases were uniform throughout the right ventricle. No variations in repolarization or in refractoriness were observed between the four ventricular sites studied.The results suggest that quinidine does not have a direct effect on dispersion of repolarization, and that mechanisms other than its direct electrophysiological action are involved in the development of torsade de pointes.

Key Words: Monophasic action potential • intracavitary recordings • quinidine


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