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European Heart Journal 1987 8(3):263-270;
Copyright © 1987 by the European Society of Cardiology.
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© 1987 The European Society of Cardiology

Long-acting coronary vasodilatory action of the molsidomine metabolite Sin I: a quantitative angiographic study

P. W. SERRUYS, J. W. DECKERS, H. E. LUUTEN*, J. H. C. REIBER, J. G. P. TUSSEN, D. CHADHA and P. G. HUGENHOLTZ

Thoraxcenter, Erasmus University and University Hospital ‘Dijkzigt’ Rotterdam, The Netherlands

Received 30 December 1985; revised 20 August 1986; .

Address for correspondence: P. W. Serruys, M.D., Catheterization laboratory, Thoraxcenter, University Hospital ‘Dijkzigt’, Dr Motenwaterplein 40, 3015 GD Rotterdam, The Netherlands.

Abstract

The vasodilatory action of molsidomine was studied by intracoronary injection of its active metabolite, Sin 1. In 10 patients repeat coronary angiography in multiple projections was performed before and 2 minutes after administration of 1 mg of Sin 1, and before and after a second injection 60 minutes later. Contours of obstructed and non-obstructed segments of the left coronary artery were quantitatively analysed with a computer-based angiography analysis system. Immediately after its administration, Sin I increased the mean diameters of 44 normal coronary segments by 12% (P<000I). Significant vasodilation (8%) was still observed after 60 minutes. At that time, repeated administration of Sin I increased the vasodilation by an additional 14% with respect to the control situation. An increase in obstruction diameter was observedin 6 out of 8 obstructed segments. Mean increase in the minimal obstruction diameter was still 10% after 60 minutes.

Key Words: Molsidomine • coronary artery disease • coronary vasodilation


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