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European Heart Journal 1987 8(3):308-312;
Copyright © 1987 by the European Society of Cardiology.
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© The European Society of Cardiology

Mechanism of hypotensive action of ketanserin in men

P. LIJNEN, R. FAGARD, J. STAESSEN, L. VANHEES and A. AMERY

Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven K. U. Leuven, Belgium

Received 28 April 1986; revised 13 August 1986; .

Address for correspondence: Dr P. Lijnen, Hypertension Unit, Campus Gasthuisberg, Herestraat 49, B-3000 Leuveo, Belgium.

Abstract

The mechanism of the hypotensive action produced by ketanserin during chronic treatment in humans remains unknown. In contrast to previous reports, recent data show that ex vivo inhibition of the serotonin-induced platelet aggregation can be demonstrated in men during chronic ketanserin administration, provided that the pH is controlled in the in vitro assay. This test could be used as a tool to measure the degree of serotonin inhibition, at least at the platelet level.

Key Words: Serotonin antagonism • hypotensive action • ketanserin.


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