Skip Navigation

European Heart Journal 1987 8(4):340-346;
Copyright © 1987 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by TIMMIS, A. D.
Right arrow Articles by SOWTON, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TIMMIS, A. D.
Right arrow Articles by SOWTON, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1987 The European Society of Cardiology

Arterial blood infusion for myocardial protection during percutaneous transluminal coronary angioplasty

A. D. TIMMIS, B. GRIFFIN, J. C. P. CRICK and E. SOWTON

Department of Cardiology, Guy's Hospital St Thomas Street, London SEl 9RT, England

Received 28 April 1986; revised 30 September 1986; .

Address for correspondence: Adam D. Timmis, Department of Cardiology, Guy's Hospital, St Thomas Street, London SE1 9RT, England.

Abstract

Much of the potential risk of percutaneous transluminal coronary angioplasty relates to regional myocardial ischaemia during balloon inflation. We have investigated the protective effect of infusing arterial blood through the angioplasty catheter into the distal coronary artery during 60 second balloon inflations. Symptomatic, electrocardiographic and echocardiographic indices of regional ischaemia were monitored during inflations with and without blood infusion. The effect of infusing Hartmann's solution was also evaluated to control for washout effects. Twelve patients were studied. Inflation without blood produced chest pain in eight patients, ST-segment elevation in ten patients and regional wall motion abnormalities in every case. During blood infusion manifestations of ischaemia were either delayed or prevented altogether. Chest pain occurred in only one patient while ST segment elevation and regional wall motion abnormalities occurred in three and four patients, respectively. Infusion of Hartmann's solution, on the other hand, had no significant effect on the development of regional myocardial ischaemia during balloon inflation indicating that delivery of arterial oxygen and not washout of metabolites was responsible for the beneficial effects of blood infusion. These data indicate that distal coronary perfusion with arterial blood during angioplasty reduces regional myocardial ischaemia and has the potential to improve the safety of the technique and to permit more prolonged periods of balloon inflation.

Key Words: Percutaneous transluminal coronary angioplasty • distal coronary perfusion • myocardial protection


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.