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European Heart Journal 1987 8(5):521-527;
Copyright © 1987 by the European Society of Cardiology.
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© 1987 The European Society of Cardiology

Chronic atrial fibrillation— epidemiologic features and 14 year follow-up: A case control study

P. T. ÖNUNDARSON, G. THORGEIRSSON, E. JONMUNDSSON, N. SIGFUSSON and Th. HARDARSON

Departments of Medicine and Radiology, Landspitalinn, University Hospital of Iceland and Heart Preventive Clinic Reykjavik, Iceland

Received 14 July 1986; revised 16 October 1986; .

G. Thorgeirsson, M.D., Ph.D., Department of Medicine, Landspitalinn, University Hospital of Iceland, Reykjavik, Iceland.

Abstract

In a randomly selected population of 9067 individuals, 32–64 years of age in 1967–1970, 25 (0.28%) had chronic atrial fibrillation (CAF). Eight had lone atrial fibrillation. In 1984 the cases were compared with an age- and sex-matched control group of 50 and found to have more cerebrovascular accidents (6 versus 2; P < 0.05), congestive heart failure (9 versus 1; P < 0.001), and valvular rheumatic heart disease (3 versus 0) or history consistent with rheumatic fever (6 versus 0; P < 0.01). The mortality in the CAF group was 60% higher due to an excess in cardiovascular (relative risk 6.1; P<0.05) and cerebrovascular (relative risk 12.2; P<0.05) causes. The prevalence or incidence of ischaemic or hypertensive heart disease or the presence of coronary risk factors did not significantly differ in the two groups. By M-mode echocardiography the left atrial size, left ventricular enddiastolic dimension and left ventricular mass were increased in the CAF patients, while the systolic left ventricular shortening was significantly less.

Thus, the prevalence of CAF is low in a randomly selected population 32–64 years of age and CAF is not strongly associated with ischaemic heart disease or hypertension. The CAF patients have an increased risk of dying prematurely particularly from cerebrovascular causes, even in the absence of valve disease.

Key Words: Chronic atrial fibrillation • epiderniologic survey • clinical follow-up • echocardigraphy


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