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European Heart Journal 1987 8(8):906-909;
Copyright © 1987 by the European Society of Cardiology.
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© 1987 The European Society of Cardiology

Treatment of prosthetic tricuspid valve thrombosis with recombinant tissue-type plasminogen activator

P. CAMBIER, P. MOMBAERTS, H. DE GEEST, D. COLLEN and F. VAN DE WERF

Division of Cardiology, University Hospitals, and the Center for Thrombosis and Vascular Research, University of Leuven Belgium

Received 29 January 1987; .

F. Van de Werf, MD, Division of Cardiology, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

Recombinant tissue-type plasminogen activator (rt-PA) was admministered intravenously to a 64-years old female with thrombotic malfunction of a Björk–Shiley prosthetic tricuspid valve. 150 mg of single-chain rt-PA was infused over 8 hours followed by an additional dose of 50 mg over the next 8 hours. At the end of the first infusion, restoration of normal valve function was demonstrated by fluoroscopic and echo-Doppler examinations. Mild systemic activation of the fibrinolytic system occurred, with a decrease of fibrinogen and {alpha}2-antiplasmin to 53% and 33%, respectively, of the preinfusion value at the nadir.

Key Words: Recombinant tissue-type plasminogen activator, • prosthetic tricuspid valve thrombosis.


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