Skip Navigation

European Heart Journal 1988 9(1):106-109;
Copyright © 1988 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by STRUNGE, P.
Right arrow Articles by ANDREASEN, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by STRUNGE, P.
Right arrow Articles by ANDREASEN, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 The European Society of Cardiology

Amiodarone during pregnancy

P. STRUNGE*,, J. FRANDSEN* and P. ANDREASEN{dagger}

*Medical Department, Horsens Sygehus DK-8700 Horsens ,Denmark
{dagger}Division of Clinical Pharmacology, Institute of Pharmacology Bartholin Building, DK-8000 Aarhus, Denmark

Received 6 April 1987; revised 19 July 1987; .

address for correspondence: Dr Poul Sygehus,, Medical Department, Horsens Sygehus, DK-8700 Horsens, Denmark

Abstract

A case study is presented in which amiodarone (A) was given during the whole of pregnancy and during the breast feeding period. An intensive observation of thyroid tests, serum concentrations of A and its metabolite, desethylamiodarone (DEA ) was undertaken. The child was observed in the same way from birth until 2 months of age. The milk was analyzed for A and DEA. As reported in other published cases, transplacental passage was found and there was a relatively high concentration of amiodarone in the milk. Our child like the other children was healthy at birth, being euthyroid and with no goiter or corneal deposits. No effect was observed of the medication on growth, thyroid tests or cornea.

It is concluded that amiodarone can be given during pregnancy but it is advisable to use as low doses as possible and control the serum concentrations at regular intervals. Breast feeding need not be forbidden.

Key Words: Amiodarone • pregnancy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
E. Martino, L. Bartalena, F. Bogazzi, and L. E. Braverman
The Effects of Amiodarone on the Thyroid
Endocr. Rev., April 1, 2001; 22(2): 240 - 254.
[Abstract] [Full Text]

Home page
 NEJMHome page
S. Ito
Drug Therapy for Breast-Feeding Women
N. Engl. J. Med., July 13, 2000; 343(2): 118 - 126.
[Full Text] [PDF]

Home page
 J Hum LactHome page
B. Fulton
Antiarrythmics in Breastfeeding
J Hum Lact, September 1, 1994; 10(3): 193 - 194.
[PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.