Copyright © 1988 by the European Society of Cardiology.
© 1988 The European Society of Cardiology
The use of atenolol in the prevention of supraventricular arrhythmias following coronary artery surgery
*Walsgrave Hospital Clifford Bridge Road, Coventry CV2 2DX, U.K.
Northern General Hospital Herries Road, SheffieldS5 7AU, U.K.
Received 23 March 1987; revised 26 June 1987; .
*R. K. lamb, FRCS, consultant Cardiac Surgon Wessex Cardiothoracic Center, Sothampton General Hospital, Leval E, East wing shirley, Southampton SO94XY, UK
Abstract
Sixty patients undergoing coronary artery bypass surgery were studied prospectively in order to investigate the effect of a cardioselective beta-blocker on the incidence of postoperative supraventricular arrhythmias. Patients with good left ventricular function were randomly divided into two groups: 30 patients treated with atenolol and 30 patients acting as controls. A trial fibrillation was seen in 11 patients and frequent premature atrial extrasystoles were noted in one. Eleven (37%) patients in the control group experienced arrhythmias whilst atenolol significantly reduced this incidence to 3% (one patient), P % 0–007. There was no significant relationship between the development of supraventricular arrhythmias and the following variables: age, sex, severity of preoperative symptoms, previous myocardial infarction, extent of coronary artery disease, technique of my ocardial preservation used, ischaemic time, number and site ofsaphenous vein grafts, endarterecto-mies performed and perioperative serum potassium levels. It is concluded that the use of atenolol (started 72 h before operation) is effective in reducing the incidence of supraventricular arrhythmias following elective coronary artery bypass operations in patients with good left ventricular function.
Key Words: Coronary artery surgery • beta-blocker • supraventricular arrhythmia
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